A technical issue saw pole leader Valentino Rossi prevented from contesting for the crown in front of a home audience as he dropped further back in the riders' standings with his second retirement of the campaign.
Victory also saw Lorenzo seal back-to-back MotoGP wins for the first time in the 2016 season and extend his lead at the summit of the riders' standings, while Andrea Iannone claimed third place on the podium.
2016 MotoGP Italian Grand Prix Results:
1- Jorge Lorenzo SPA Movistar Yamaha MotoGP Yamaha 41'36.535
2- Marc Marquez SPA Repsol Honda Team Honda +0.019
3- Andrea Iannone ITA Ducati Team Ducati +4.742
4- Dani Pedrosa SPA Repsol Honda Team Honda +4.910
5- Andrea Dovizioso ITA Ducati Team Ducati +6.256
6- Maverick Vinales SPA Team SUZUKI ECSTAR Suzuki +8.670
7- Bradley Smith GBR Monster Yamaha Tech 3 Yamaha +13.340
8- Danilo Petrucci ITA OCTO Pramac Yakhnich Ducati +14.598
9- Aleix Espargaro SPA Team SUZUKI ECSTAR Suzuki +18.643
10- Michele Pirro ITA Ducati Team Ducati +22.298